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An Introduction To Cystatin C & It’s Importance

Gfap Test is a simple blood test that can measure the accumulation of certain proteins in the brain indicative of glial cell activation. Studies suggest a GFAP protein can help maintain cell shape and astrocyte mechanical strength. Type III intermediate filament proteins comprise three domains, head, rod, and tail. The rod domain may differ in its DNA sequence, but its protein structure is highly conserved. One such example is GFAP (Glial Fibrillary Acidic Protein). Normally found in the gray matter, it can polymerize other proteins within the type III group. Additionally, GFAP comprises eight different isoforms that make up distinct astrocyte subpopulations in the human brain. Out of these isoforms, GFAP alpha is the only one that can assemble homomerically.

The GFAP test is a laboratory test used to detect the presence of glial fibrillary acidic protein (GFAP). GFAP is a structural protein found in the central nervous system that makes up the intermediate filaments. The GFAP test is used to assist in diagnosing tumors and other diseases involving astrocytes, which are star-shaped glial cells that provide nourishment and protection for neurons. The GFAP test may also be called a gliastatin test or an astroglial-specific protein.

The glial fibrillary acidic protein (GFAP) test is a cell test that detects an immunoglobulin labeled GFAP protein in body tissues. This proliferation marker is typically used to count cells in astroglial tumors, e.g., astrocytoma. GFAP can be measured with immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), or western blot assays. There are three different types of GFAP proteins: type I, type II, and type III.

Cystatin C function is an important kidney biomarker. Researchers first described Cystatin C as a gamma trace found in the urine and cerebrospinal fluid of patients with kidney failure. All nucleated human cells produce cystatin C. CST3 gene encodes cystatin C, which belongs to the gene family of type 2 cystatin. The CST3 gene is present in the cystatin locus on chromosome 9. Cystatin C is a type of non-glycosylated protein characterized by long and short alpha-helices that reside in the head of the protein sequence. Cystatin C is encoded by the CST3 gene, which belongs to a gene family of type 2 cystatin, and is present on the chromosome 9. Researchers mostly use cystatin C levels to determine Cystatin C glomerular filtration rate (GFR). However, recent studies also explore cystatin C’s role in predicting cardiovascular diseases and association with amyloid plaques in neurological disorders.

Cystatin C is a renal biomarker with immunofluorescent staining, which serves as an apt marker to visualize and identify (ectopic) solitary kidney. Solitary kidney results from duplication of the ureteric bud which leads to the formation of bilateral blind-ended tubules. As this condition rarely involves newborns, the vast majority of cases involves young adults and the elderly.

The Cystatin C test is a blood test ordered by a doctor that measures cystatin C in your blood. Cystatin C levels reflect the amount of protein that is made by the kidneys, and reflects how well they are working. The test is used to monitor your kidney health, especially if you have issues with diabetes or high blood pressure.

Eleena Wills
Hi, I’m Eleena Wills. Being a writer and blogger, I strive to provide informative and valuable articles to people. With quality, constructive, and well-researched articles, one can make informed choices. I cover a wide range of topics, from home improvement to hair styling and automotive.


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